77985-11-6

Upstream product

• 186581-53-3 diazomethane 
• 71548-88-4 Beclobric acid 
• 5398-71-0 2-bromo-2-ethyl-2-methyl acetic acid ethyl ester 
• 52890-73-0 4-(4-chloro-benzyl)-phenol 
• 55937-99-0 beclobrate 

Relevant academic research and scientific papers

Investigation on metabolism of beclobrate in rat and man

The major pathway of biotransformation of beclobrate [(2-[4-[(4-chlorophenyl)methyl]phenoxy]-2-methylbutyric acid ethyl ester] is the ester cleavage to beclobrinic acid (M1), which is eliminated as glucuronide. Subsequent metabolic attack occurs via oxidation of the methylene bridge to the carbinol (M2) as well as to the benzophenone (M3). The p-chloro substituted phenyl ring is oxidated via a postulated areneoxide to the 2'- and 3'-phenol metabolites (M5 and M6) and to the trans-2',3'-dihydrodiol (M4). Except for M4, all metabolites are eliminated exclusively as glucuronides.

Phenoxy alkanoic acid derivatives having the ability to lower the level of fatty substances in the blood

Novel compounds of the formula STR1 wherein R1 is hydrogen, halogen, or alkyl or alkoxy containing from 1 to 4 carbon atoms, R2 is hydrogen, halogen, hydroxy or alkyl of alkoxy containing from 1 to 4 carbon atoms, n and m are integers such that the sum (n+m) lies in the range from 3 to 10 inclusive and n differs from m, and x is alkyl containing from 1 to 4 carbon atoms, hydrogen or a cation which is a metal cation of main Groups 1, 2 and 3 of the Periodic System of the Elements, an organic base cation or an ammonium ion. These compounds have pharmaceutical utility by virtue of their considerable ability to reduce the level of fatty substances in the blood.

Beclobrate and eniclobrate hydrochloride, new diphenylmethane derivatives as agents for lowering cholesterol and triglyceride levels. Part I: Synthesis and consideration of structure-activity relationships (author's transl)

Within the course of a research project for finding new lipid-lowering substances with better therapeutic indices than the standard agent in use, various diphenylmethane derivatives were synthesized and tested with respect to their activity and toxicity. On the basis of these results Sgd 24774 (beclobrate) and Sgd 33374 (eniclobrate-hydrochloride) were selected for further investigation and clinical studies.