77991-97-0

Usage

Chemical structure

Thiourea derivative with a cyclopropyl group and a phenyl group attached to the nitrogen atom

Biological activities

Various, including inhibitory effects on certain enzymes and anti-inflammatory properties

Pharmaceutical applications

Potential use in the development of new drugs due to its diverse properties

Enzyme inhibition

Known to inhibit certain enzymes, which may contribute to its biological activities

Anti-inflammatory properties

Exhibits anti-inflammatory effects, which could be useful in the treatment of inflammation-related conditions

Pesticide and herbicide potential

Investigated for its potential use as a pesticide and herbicide, indicating its ability to control or kill unwanted organisms

Diverse properties

Demonstrates a range of properties, making it a versatile compound with potential applications in various fields

Research focus

Has been studied for its potential pharmaceutical applications, as well as its use in agriculture and other industries

Chemical classification

Belongs to the class of thiourea derivatives, which are known for their diverse chemical and biological properties

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 765-30-0 Cyclopropylamine 

Relevant academic research and scientific papers

Computational and experimental studies of 4-thiazolidinone-cyclopropyl hybrid

Thiazolidi-4-one is a significant pharmacophore and has been known to exhibit a diverse range of biological activities for a long time. A new compound (6), thiazolidi-4-one was synthesized and characterized by spectroscopic techniques and X-ray single cry

Facile synthesis of phthalidyl fused spiro thiohydantoins through silica sulfuric acid induced oxidative rearrangement of ninhydrin adducts of thioureas

A one-pot three-component sequential synthetic protocol produces structurally and biologically important phthalidyl fused spiro N,N′-disubstituted thiohydantoins from readily available aromatic isothiocyanates, primary amines and ninhydrin. In this three-step synthesis while the initial two steps are catalyst-free, in the final step silica sulfuric acid (SSA) induces an oxidative rearrangement in [3.3.0]-bicyclic 1,2-diol adducts of ninhydrin and thioureas under solvent-free condition to generate the final products spiro-fused thiohydantoins. The adequate acidity of SSA in cooperation with moderate oxidizing property promotes a facile oxidative rearrangement in 1,2-diol intermediates to produce the spiro-fused thiohydantoins with diverse functionalities. Easy recyclability of SSA, good to excellent yield of the products, wider substrate scope, shorter reaction time, solvent-free two steps out of three and high atom economy make this method attractive and practicable.