77992-29-1

Basic information

• Product Name: 4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine monohydrochloride
• Synonyms: 4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine monohydrochloride;4,5-Dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine Hydrochloride
• CAS NO: 77992-29-1
• Molecular Formula: C₁₀H₁₀F₃N₃*ClH
• Molecular Weight: 265.6626496
• EINECS: 278-807-4
• Mol File: 77992-29-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 308.5°C at 760 mmHg
• Flash Point: 140.4°C
• Appearance: /
• Vapor Pressure: 0.00068mmHg at 25°C
• CAS DataBase Reference: 4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine monohydrochloride(77992-29-1)
• EPA Substance Registry System: 4,5-dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine monohydrochloride(77992-29-1)

Safety Data

• Hazardous Substances Data: 77992-29-1(Hazardous Substances Data)

Usage

Uses

4,5-Dihydro-1-[3-(trifluoromethyl)phenyl]-1H-pyrazol-3-amine Hydrochloride is used as a reagent in the synthesis of benzimidazolylbiarylacetamides as vanilloid TRVP1 inhibitors for the treatment of pain and respiratory disorders.

InChI:InChI=1/C10H10F3N3.ClH/c11-10(12,13)7-2-1-3-8(6-7)16-5-4-9(14)15-16;/h1-3,6H,4-5H2,(H2,14,15);1H

Upstream product

• 107-13-1 acrylonitrile 
• 368-78-5 3-(trifluoromethyl)phenylhydrazine 

Downstream Products

• 325851-10-3 3-salicylidenamino-1-(3-trifluoromethylphenyl)-2-pyrazoline 

Relevant articles and documents

2-(BENZIMIDAZOL-1-YL)-ACETAMIDE BIARYL DERIVATIVES AND THEIR USE AS INHIBITORS OF THE TRPV1 RECEPTOR

The invention relates to 2-(benzimidazol-1-yl)-acetamide bisaryl derivative having the general Formula (I) wherein n is 0 or 1; Ar1 represents a diradical derived from a 5- or 6-membered aromatic ring, optionally comprising 1-3 heteroatoms selected from N, O and S, said ring being optionally substituted with (C1-4)alkyl, (C1-4)alkyloxy, halogen, CF3 or cyano; Ar2 represents a 6-membered aryl ring, optionally comprising 1-3 nitrogen atoms, said ring being optionally substituted with 1-3 substituents selected from (C1-4)alkyl (optionally substituted with 1 or more halogens), (C1-4)alkyloxy (optionally substituted with 1 or more halogens), di(C1-4)alkylamino, halogen, CF3 or cyano; or a pharmaceutically acceptable salt thereof; to pharmaceutical compositions comprising the same and to the use of said 2-(benzimidazol-1-yl)-acetamide bisaryl derivatives in the treatment of TRPV1 mediated disorders.