77997-19-4

Upstream product

• 97091-03-7 5-benzoylamino-2-(p-aminosulfonyl)anilino-4-hydroxy-pyrimidine 
• 77997-17-2 5-amino-2-(p-aminosulfonyl)anilino-4-hydroxy-pyrimidine 
• 22818-40-2 D-4-hydroxyphenylglycine 
• 89074-09-9 2-(p-aminosulfonyl)anilino-5-chlorocarbonylamino-4-hydroxy-pyrimidine 

Relevant academic research and scientific papers

Synthesis and antibacterial activity of pyrimidinylureidopenicillins

The 6R-[(R)-2-[3-[5-pyrimidinyl]ureido]-2-(4-hydroxyphenyl)acetamido]-penicill anic acids, prepared by two synthetic routes, exhibit broad antimicrobial activity against Gram-positive and Gram-negative bacteria. Their structure-activity relationships are discussed. 6R-[(R)-2-[3-[2-(p-aminosulfonyl)anilino-4-hydroxy-5-pyrimidinyl]ureido]-2 -(4-hydroxyphenyl)acetamido]-penicillanic acid, sodium salt (VX-VC 43), the most active compound, shows very low MIC (minimal inhibitory concentration) values against clinically important Gram-negative bacteria, primarily Pseudomonas aeruginosa.