78004-47-4Relevant academic research and scientific papers
Regioselectivity in Deprotonation of Imines Derived from 3-Pentanone
Smith, Kirk J.,Bergbreiter, David E.,Newcomb, Martin
, p. 3157 - 3158 (2007/10/02)
Regioselectivity in deprotonation of (Z)-tert-butyl,(Z)-cyclohexyl,(Z)-benzyl,and (Z)-phenyl ketimines of 3-pentanone has been shown to be generally low and variable.Deprotonation of 13CH3-labeled Z ketimines with either lithium diisopropylamide or lithium diethylamide in THF and methylation at -78 deg C was used to determine regiochemistry.Syn/anti deprotonation ratios varied from 74/26 to 22/78 with different ketimines and different bases.
