78018-76-5Relevant academic research and scientific papers
Kinetics and Mechanisms of Nucleophilic Displacements with Heterocycles as Leaving Groups. 2. N-Benzylpyridinium Cations: Rate Variation with Steric Effects in the Leaving Group
Katritzky, Alan R.,El-Mowafy, Azzahra M.,Musumarra, Giuseppe,Sakizadeh, Kumars,Sana-Ullah, Choudhry,et al.
, p. 3823 - 3830 (2007/10/02)
N-Benzyl groups are transferred to piperidine from pyridinium ions by unimolecular SN1 and/or bimolecular SN2 mechanisms.Steric acceleration by α-phenyl groups is reduced by an adjacent β-methyl group but increased by constraining th
Kinetics and Mechanism of the Reactions of Primary Amines with Pyrylium Cations
Katritzky, Alan R.,Manzo, Ruben H.
, p. 571 - 575 (2007/10/02)
The initial reaction of primary amines with pyrylium cations to give the ring-opened intermediate is fast for strongly basic amines and is base-catalysed for weak amines.Ring-closure of the intermediate to give the pyridinium derivative is subject to ster
