78019-76-8Relevant academic research and scientific papers
Studies in Tertiary Amine Oxides. Part V - Carbon-13 Nuclear Magnetic Resonance Spectra of some N-Aryl Tertiary Amines, the Corresponding N-Oxides and the Meisenheimer Rearrangement Products
Khuthier, Abdul-Hussain,Al-Rawi, Jasim M. A.,Al-Kazzaz, Abdul K.,Al-Iraqi, Mohammed A.
, p. 104 - 108 (1982)
The carbon-13 NMR spectra of some N-(2- or 4-nitrophenyl) tertiary amines and their corresponding N-oxides have been analysed.These N-oxides undergo thermal rearrangement to O-arylhydroxylamines, for which the 13C NMR spectral assignments were also carried out.The N-oxidation effect on the aromatic and aliphatic fragments is calculated.
Potent 2′-aminoanilide inhibitors of cFMS as potential anti-inflammatory agents
Patch, Raymond J.,Brandt, Benjamin M.,Asgari, Davoud,Baindur, Nand,Chadha, Naresh K.,Georgiadis, Taxiarchis,Cheung, Wing S.,Petrounia, Ioanna P.,Donatelli, Robert R.,Chaikin, Margery A.,Player, Mark R.
, p. 6070 - 6074 (2008/03/18)
A series of 2′-aminoanilides have been identified which exhibit potent and selective inhibitory activity against the cFMS tyrosine kinase. Initial SAR studies within this series are described which examine aroyl and amino group substitutions, as well as the introduction of hydrophilic substituents on the benzene core. Compound 47 inhibits the isolated enzyme (IC50 = 0.027 μM) and blocks CSF-1-induced proliferation of bone marrow-derived macrophages (IC50 = 0.11 μM) and as such, serves as a lead candidate for further optimization studies.
Studies of Tertiary Amine Oxides. 4. Thermal Rearrangement of N-Aryl Amine Oxides to O-Arylhydroxylamines
Khuthier, Abdul-Hussain,Al-Kazzaz, Abdul-Khalik S.,Al-Rawi, Jasim M. A.,Al-Iraqi, Mohammed A.
, p. 3634 - 3638 (2007/10/02)
Substituted N-aryl cyclic amine oxides undergo novel thermal rearrangement to O-arylhydroxylamines.Electron-withdrawing substituents are essential for the rearrangement and must be ortho or para relative to the N->O function.The mechanism of the rearrangement is best described by an intramolecular cyclic process.Kinetic results are in agreement with the cyclic process but are inconsistent with a homolytic dissociation-recombination mechanism.
