78031-09-1Relevant academic research and scientific papers
Frustrated Lewis-Pair-Meditated Selective Single Fluoride Substitution in Trifluoromethyl Groups
Gupta, Richa,Jaiswal, Amit K.,Mandal, Dipendu,Young, Rowan D.
supporting information, p. 2572 - 2578 (2020/03/03)
Single fluoride substitution in trifluoromethylarenes is an ongoing synthetic challenge that often leads to "over-reaction", where multiple fluorides are replaced. Development of this reaction would allow simple access to a vast range of difluoromethyl derivatives of current interest to pharmaceutical, agrochemistry, and materials sciences. Using a catalytic frustrated Lewis pair approach, we have developed a generic protocol that allows a single substitution of one fluoride in trifluoromethyl groups with neutral phosphine and pyridine bases. The resulting phosphonium and pyridinium salts can be further functionalized via nucleophilic substitution, photoredox coupling, and electrophilic transfer reactions allowing the generation of a vast array of difluoromethyl products.
Preparation of a difluorohalomethoxybenzene
-
, (2008/06/13)
A higher yield of the difluorohalomethoxybenzene produced by the reaction of a metal phenolate with dibromodifluoromethane or bromochlorodifluoromethane can be obtained by conducting the addition of a metal alcoholate or a metal hydride as a reaction init
SPONTANEOUS REACTIONS OF POTASSIUM PHENOXIDE WITH DIBROMOPERFLUOROALKANES. FIRST EVIDENCE FOR BROMOPHILIC ATTACK ON C-Br BONDS BY THE PHENOXIDE ION.
Xingya, Li,Heqi, Pan,Xikui, Jiang
, p. 4937 - 4940 (2007/10/02)
In contrast to earlier reports, It has been found that dibromoperfluoroalkanes actually can react spontaneously with PhOK, yielding fluoroalkyl phenyl ethers as products.Evidence for an anionic chain mechanism involving a bromophilic attack by the phenoxyde ion is presented.
SYNTHESE DE COMPOSES AROMATIQUES COMPORTANT LES GROUPEMENTS OCF2Br ET SCF2Br-II; ACTION DE CF2Br2 ET DE CF2BrCl SUR DES THIOPHENATES ET PHENATES DE POTASSIUM DIVERSEMENT SUBSTITUES
Rico, I,Wakselman, C.
, p. 4209 - 4214 (2007/10/02)
The reaction of dibromodifluoromethane and bromochlorodifluoromethane with substituted potassium thiophenoxides and phenoxides leads to the formation of new aromatic compounds bearing OCF2Br and SCF2Br groups.
SYNTHESE DE COMPOSES AROMATIQUES COMPORTANT LES GROUPEMENTS OCF2Br ET SCF2Br; I - Action du dibromodifluoromethane sur les thiophenate et phenate de potassium
Rico, Isabelle,Wakselman, Claude
, p. 323 - 326 (2007/10/02)
The synthesis of C6H5OCF2Br and C6H5SCF2Br from CF2Br2 is described.
