78031-85-3Relevant academic research and scientific papers
Penicillin acylase-catalyzed peptide synthesis in aqueous medium: A chemo-enzymatic route to stereoisomerically pure diketopiperazines
Khimiuk, Andrei Y.,Korennykh, Alexei V.,Van Langen, Luuk M.,Van Rantwijk, Fred,Sheldon, Roger A.,Svedas, Vytas K.
, p. 3123 - 3128 (2007/10/03)
A range of non-natural dipeptides of the general formula D-(-)-phenylglycyl-L-X, where X is a natural α-amino acid, have been prepared by penicillin acylase-catalyzed synthesis in aqueous medium from D-(-)-phenylglycine amide and the corresponding amino acids. The conversion of the dipeptides to the corresponding dipeptide esters, followed by their subsequent spontaneous cyclization afforded the corresponding stereoisomerically pure diketopiperazines.
ASYMMETRIC TRANSFORMATION OF AMINO ACIDS IN N-SALICYLIDENE AMINO ACYL-L-ISOLEUCINATOCOPPER(II)
Harada, Kaoru,Shiono, Katsuji,Nomoto, Shinya
, p. 1271 - 1274 (2007/10/02)
A new asymmetric transformation of amino acids was described.Thus, when N-salicylidene-D-alanyl-, D-phenylalanyl-, or D-phenyl-glycyl-L-isoleucinatocopper(II) was incubated at pH 8.5 and 80 deg C, the resulting mixture at equilibrium contained a complex of L-L-dipeptide in the contents of 63-76percent.The epimerization of dipeptides is based on the enhanced activity of N-terminal amino acids through complex formation.
