78034-61-4Relevant academic research and scientific papers
Visible-light-induced acetalization of aldehydes with alcohols
Yi, Hong,Niu, Linbin,Wang, Shengchun,Liu, Tianyi,Singh, Atul K.,Lei, Aiwen
, p. 122 - 125 (2017)
In this work, we have achieved a simple and general method for acetalization of aldehydes by means of a photochemical reaction under low-energy visible light irradiation. A broad range of aromatic, heteroaromatic, and aliphatic aldehydes have been protected under neutral conditions in good to excellent yields using a catalytic amount of Eosin Y as the photocatalyst. Our visible light mediated acetalization strategies are successful for more challenging acid-sensitive aldehydes and sterically hindered aldehydes. Notably, this protocol is chemoselective to aldehydes, while ketones remain intact.
Method for synthesis of acetal derivative by photocatalysis
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Paragraph 0043, (2017/04/19)
The invention discloses a method for synthesis of an acetal derivative by photocatalysis. The method consists of: in the presence of a photocatalyst, dissolving aldehyde and lower alcohol in an organic solvent, mixing the substances evenly, then carrying out reaction for 4-12h in an inert gas atmosphere and under a 300-600nm wavelength illumination condition, and then carrying out separation and purification, thus obtaining the acetal derivative. According to the invention, aldehyde, lower alcohol and the photocatalyst are employed to construct the acetal derivative by one step directly under room temperature illumination, the preparation method is simple, has mild conditions, and can prepare the target product high selectively; the raw materials are cheap and easily available, green and economical, also the method has very good substrate applicability, greatly expands the substrate range, and has very great application potential in biomedical synthetic intermediates.
