78048-70-1Relevant academic research and scientific papers
Antidepressant piperidine derivatives
-
, (2008/06/13)
Compounds of formula: STR1 and pharmaceutically acceptable acid addition or quaternary ammonium salts thereof wherein the piperidine ring is substituted in the 3 or 4 position; X represents =CH-- or =N--; Y represents --NR5 --, --O-- or --S-- wherein R5 is hydrogen or lower alkyl; A is lower alkylene or hydroxy lower alkylene, Z and Z1 independently represent STR2 Z may also represent --CH2 --, --(CH2)2 --, --CHMe-- or --CMe2 --; R1, R2, R3 independently represent hydrogen, halogen, lower alkyl, lower alkoxy, nitro, amino, lower alkylamino, trifluoromethyl, lower-alkanoylamino, hydroxy or aryl lower alkoxy; or R1 and R2 when adjacent together with the carbons to which they are attached form a six membered carbocyclic ring; and R4 represents hydrogen or lower alkyl, are disclosed which possess psychotropic activity and are useful as anti-depressants.
