78053-04-0Relevant academic research and scientific papers
Preparation of 1-adamantyl ketones: Structure, mechanism of formation and biological activity of potential by-products
Vicha, Robert,Necas, Marek,Potacek, Milan
, p. 709 - 722 (2008/02/01)
Reactions between adamantane-1-carbonyl chloride and several Grignard reagents as well as interactions with solvents have been examined. Some new and unexpected adamantane derivatives were isolated, fully characterized and their biological activity determined. In particular, an unexpected isochromanone 16 was formed in an SEAr process, in which a stable hydrocarbon was the leaving group.
TRIFLUOROACETIC ANHYDRIDE AS A MEDIUM FOR ORGANIC REACTIONS. FUNCTIONAL SUBSTITUTION OF ADAMANTANE AND ITS DERIVATIVES
Kovalev, V. V.,Fedorova, O. A.,Shokova, E. A.
, p. 1672 - 1675 (2007/10/02)
The role of trifluoroacetic anhydride during the oxidation of adamantane and its derivatives with sulfuric acid was studied. 1-Adamantanol, 1-(4-methyl-3-nitrophenyl)-3-adamantanol.The latter was used without isolation from the reaction mixture for the production of 1-adamantanecarboxylic acid, N-(1-adamantyl)acetamide, 1-(1-adamantyl)butan-1-ol, 1-(4-methylphenyl)adamantane, 4-(1-adamantyl)phenoxyacetic acid, 4-(1-adamantyl)acetanilide, and 4-(1-adamantyl)bromobenzene.
Synthesis of 1-adamantyl and 1-adamantylmethyl alkyl ketones
Grava, I. Ya.,Polis, Ya. Yu.,Lidak, M. Yu.,Liepin'sh, E. E.,Shatts, V. D.,et al.
, p. 679 - 686 (2007/10/02)
The reaction of 1-adamantanecarboxylic and 1-adamantylacetic acids with Grignard reagents in the presence of cuprous chloride or iodide gave the corresponding ketones.
