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Z-pGlu-Ser(t-Bu)-Pro-NH2 is a synthetic peptide consisting of four amino acid residues: Z-protected glutamic acid (Z-pGlu), serine with a tert-butyl group (Ser(t-Bu)), proline (Pro), and an amino group (NH2) at the C-terminus. This peptide is often used in chemical biology and medicinal chemistry for studying protein-protein interactions, as well as for the development of potential therapeutic agents. The Z-protecting group on the glutamic acid residue is crucial for preventing unwanted side reactions during peptide synthesis, while the tert-butyl group on serine provides steric hindrance, which can influence the peptide's conformation and interactions with other molecules. The sequence and modifications in this peptide can be tailored for specific biological targets, making it a versatile tool in research and drug discovery.

78058-27-2

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78058-27-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 78058-27-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,0,5 and 8 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 78058-27:
(7*7)+(6*8)+(5*0)+(4*5)+(3*8)+(2*2)+(1*7)=152
152 % 10 = 2
So 78058-27-2 is a valid CAS Registry Number.

78058-27-2Downstream Products

78058-27-2Relevant academic research and scientific papers

Synthesis of Thyrotropin-Releasing Hormone Analogues. 1. Complete Dissociation of Central Nervous Effects from Thyrotropin-Releasing Activity

Szirtes, Tamas,Kisfaludy, Lajos,Palosi, Eva,Szporny, Laszlo

, p. 741 - 745 (2007/10/02)

Twenty-four thyrotropin-releasing hormone (TRH) analogues containing mainly aliphatic amino acids in position 2 were synthesized and tested for central nervous system (CNS) and hormonal (TSH) activity.Application of the pentafluorophenyl ester method in t

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