78075-73-7

Upstream product

• 69350-13-6 N-benzylidene-(S)-α-methylbenzylamine 
• 81357-56-4 Thioisobutyric acid S-pyridin-2-yl ester 
• 21678-37-5 N,N,2-trimethylpropionamide 
• 3129-98-4 (S)-N-benzylidene(1-phenylethylamine) 

Relevant academic research and scientific papers

Stereoselective synthesis of β-lactams by condensation of titanium enolates of 2-pyridylthioesters with imines bearing a chiral auxiliary

Addition of the titanium enolates of 2-pyridylthioesters to imines featuring easily removable chiral auxiliaries affords β-lactams in a highly stereoselective fashion.

Diastereoface-Differentiating Synthesis of Substituted β-Lactams from Chiral Imines and/or Chiral α-Chloro Iminium Chlorides

Reaction of imines carrying a chiral substituent at a nitrogen atom with symmetric or prochiral α-chloro iminium chlorides leads in a diastereoface-differentiating reaction to a mixture of diatereoisomeric or epimeric β-lactams.Attempts were made to determine the absolute configuration of obtained chiral β-lactams.Reaction of prochiral imines with chiral α-chloro iminium chlorides also provides mixtures of diastereomeric β-lactams or their enantiomers with a clear selectivity.