78075-92-0Relevant academic research and scientific papers
Toxicity of singlet oxygen generated thermolytically in Escherichia coli
Nagano,Tanaka,Mizuki,Hirobe
, p. 883 - 887 (1994)
Three water-soluble devivatives of naphthalene endoperoxide were prepared to examine the toxicity of singlet oxygen towards Escherichia coli. On incubation without irradiation, these endoperoxides produce singlet oxygen thermolytically in a dose-dependent manner. The amount of singlet oxygen produced per unit time can be controlled by varying both the incubation temperature and the number of methyl substituents of the naphthalene endoperoxide derivatives. 3-(1,4-Dihydro-1,4-epidioxy-4-methyl-1-naphthyl)propionic acid (EP-1), one of the derivatives, inhibited E. coli growth dose- and incubation temperature-dependently and caused E. coli lethality. Furthermore, EP-1 did not induce superoxide dismutase or catalase in E. coli even when the cells were incubated in nutritionally rich medium containing trypticase/soy/yeast extract. Singlet oxygen, one of the reactive oxygen species, did not act as a signal for induction of superoxide dismutase and catalase, in contrast to the actions of superoxide and hydrogen peroxide.
Search for Singlet Oxygen in the Decomposition of Hydrogen Peroxide by Mineral Compounds in Aqueous Solutions
Aubry, J. M.
, p. 5844 - 5849 (2007/10/02)
The possibility of singlet oxygen (1O2) occurrence in the decomposition of H2O2 by mineral compounds in aqueous basic solutions was examined.Tetrapotassium rubrene-2,3,8,9-tetrcarboxylate was used as a trap, giving an endoperoxide detected by HPLC.We found that four families of mineral compounds lead to the formation of the endoperoxide: the oxides of the alkaline earths Ca, Sr, and Ba; the derivatives of elements of groups 3A, 4A, 5A, and 6A in d0 configuration (expect niobium); the oxides of actinides and lanthanides; and finally the oxidizers ClO-, BrO-, Au3+, IO3-, and IO4-.One compound in each family was selected for further investigation in order to strengthen the 1O2 hypothesis.Thus, the yield of the endoperoxide of potassium 9,10-diphenylanthracene-2,3,6,7-tetracarboxylate was enhanced when the parent compound was introduced in a mixture of H2O2 + (ClO-, Nd2O3, MoO42-, Ca(OH)2 + deuterated water instead of light water.
