780753-89-1

Basic information

• Product Name: 1-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE
• Synonyms: 1-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE;1-(4-Fluorophenyl)-2-piperazinone
• CAS NO: 780753-89-1
• Molecular Formula: C₁₀H₁₁FN₂O
• Molecular Weight: 194.21
• Mol File: 780753-89-1.mol

Chemical Properties

• Boiling Point: 414 °C at 760 mmHg
• Flash Point: 204.2 °C
• Appearance: /
• Density: 1.225
• Vapor Pressure: 4.59E-07mmHg at 25°C
• Refractive Index: 1.542
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 1-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE(780753-89-1)
• EPA Substance Registry System: 1-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE(780753-89-1)

Safety Data

• Hazardous Substances Data: 780753-89-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
1-(4-Fluoro-phenyl)-piperazin-2-one is used as a research compound for its potential pharmaceutical applications, particularly in the development of new drugs targeting the central nervous system.
Used in Central Nervous System Depressant Applications:
In the pharmaceutical industry, 1-(4-Fluoro-phenyl)-piperazin-2-one is used as a central nervous system depressant for its sedative and anxiolytic effects, as demonstrated in animal models.
Used in Anti-Inflammatory and Analgesic Applications:
1-(4-Fluoro-phenyl)-piperazin-2-one is also used as a potential anti-inflammatory and analgesic agent, given its exploration for these properties in the development of new medications to treat pain and inflammation.

InChI:InChI=1/C10H11FN2O/c11-8-1-3-9(4-2-8)13-6-5-12-7-10(13)14/h1-4,12H,5-7H2

Upstream product

• 460-00-4 1-Bromo-4-fluorobenzene 
• 1284243-44-2 tert-butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate 
• 5625-67-2 2-Ketopiperazine 
• 352-34-1 4-fluoro-1-iodobenzene 

Downstream Products

• 1146411-57-5 4-[(2,3-dichlorophenyl)carbonyl]-1-(4-fluorophenyl)-2-piperazinone 
• 1146411-56-4 4-{[2-chloro-3-(trifluoromethyl)phenyl]carbonyl}-1-(4-fluorophenyl)-2-piperazinone 

Relevant articles and documents

TETRAHYDROQUINAZOLINONE DERIVATIVES AS PARP INHIBITORS

Disclosed are compounds of formula (I), their tautomeric forms, stereoisomers, and pharmaceutically acceptable salts thereof, wherein R1-R6, R7a-d, R8a-d, A, M, n, and p are as defined in the specification, pharmaceutical compositions including a compound, tautomer, stereoisomer, or salt thereof, and methods of treating or preventing diseases or disorders, for example, cancer, that are amenable to treatment or prevention by inhibiting the PARP enzyme of a subject.

4-BENZ0YL-1-SUBSTITUTED-PIPERAZIN-2-0NE DERIVATIVES AS P2X7 MODULATORS

The invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein: A is C1-6alkyl, C3-6cycloalkyl, -CH2-R6, -CHMe-R7, -CMe2-R7, or optionally substituted aryl; wherein, when A is optionally substituted aryl, said aryl group is optionally substituted with 1 to 3 substituents, which may be the same or different, selected from the group consisting of halogen, C1-6alkyl, -CF3, C1-4alkoxy, C1fluoroalkoxy, cyano, NR8R9; and pyridyl wherein the pyridyl is optionally substituted by one methyl; R1 is chlorine, fluorine, -CF3, cyano or C1-6alkyl; R2, R3 and R5 independently are hydrogen, fluorine, chlorine, -CF3, cyano or C1-6alkyl, such that at least one of R2, R3 and R5 is other than hydrogen; R4 is hydrogen. These compounds and salts are thought to be P2X7 receptor antagonists. The invention also provides the use of the compound or salt for the manufacture of a medicament for the treatment of pain, inflammation, rheumatoid arthritis, osteoarthritis, or a neurodegenerative disease.