780760-08-9

Upstream product

• 779340-43-1 [1-(5-methylfuran-2-yl)-(E)-methylidene]-((R)-1-phenyl-2-trimethylsilanyloxyethyl)amine 
• 925-90-6 ethylmagnesium bromide 
• 56613-80-0 D-2-phenylglycinol 
• 779340-42-0 (R)-2-{[1-(5-methylfuran-2-yl)-(E)-methylidene]amino}-2-phenylethanol 
• 620-02-0 5-Methylfurfural 

Downstream Products

• 1092389-28-0 (R)-1-(5-methyltetrahydrofuran-2-yl)propylamine para-toluenesulfonate salt 
• 1092389-21-3 2-hydroxy-N,N-dimethyl-3-{2-[(R)-1-(5-methyltetrahydrofuran-2-yl)propylamino]-3,4-dioxocyclobut-1-enylamino}benzamide 
• 1092389-32-6 (R)-1-((2R,5R)-5-methyltetrahydrofuran-2-yl)propylamine para-toluenesulfonate salt 
• 1092389-20-2 2-hydroxy-N,N-dimethyl-3-{2-[(R)-1-((2R,5S)-5-methyltetrahydrofuran-2-yl)propylamino]-3,4-dioxocyclobut-1-enylamino}benzamide 
• 1092388-85-6 6-chloro-2-hydroxy-N,N-dimethyl-3-{2-[(R)-1-((2R,5R)-5-methyltetrahydrofuran-2-yl)propylamino]-3,4-dioxocyclobut-1-enylamino}benzenesulfonamide 
• 779340-44-2 (R)-2-[(R)-1-(5-methylfuran-2-yl)propylamino]-2-phenylethanol 

Relevant academic research and scientific papers

ANTI -INFLAMMATORY SUBSTITUTED CYCLOBUTENEDIONE COMPOUNDS

The present invention relates to compounds of formula (I) with the substituents as defined herein, and uses thereof.

Synthesis of 2-hydroxy-N,N-dimethyl-3-[[2-[1(R)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-l]aminobenzamide

Disclosed is a process for making the compound of formula I: using the compounds of formulas II, Q, and XI or XII: wherein A is selected from the group consisting of Br, Cl and I (with Br being preferred); and R represents (C1-C10)alkyl. Also disclosed are intermediate compounds that are made in the disclosed process.