78083-90-6

Upstream product

• 58-74-2 Papaverine 
• 74-88-4 methyl iodide 

Downstream Products

• 81694-30-6 6'-Hydroxymethyl-9-methyl-papaverin 
• 58024-45-6 1-(6,7-dimethoxyisoquinolin-1-yl)-1-(3,4-dimethoxyphenyl)ethylene 
• 81694-31-7 threo-6'-Hydroxymethyl-9-methyl-laudanosine 
• 81694-31-7 erythro-6'-Hydroxymethyl-9-methyl-laudanosine 
• 81694-35-1 erythro-6'-Ethoxycarbonyloxymethyl-9-methyl-laudanosin 
• 81694-33-9 9-Methyllaudanosine 
• 81694-29-3 9-Methyl-norlaudanosin 

Relevant academic research and scientific papers

Iron-Catalyzed Aerobic Oxidation of (Alkyl)(aryl)azinylmethanes

An iron-catalyzed aerobic oxidation of (alkyl)(aryl)azinylmethanes has been developed leading to tertiary alcohols in moderate to good yields. Hock rearrangement was identified as a major side reaction leading to a complex mixture of undesired products. Addition of thiourea sometimes allows inhibiting this side reaction and steers the reaction towards the desired products.

ALKYLATION OF 1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXYISOQUINOLINE (PAPAVERINE)

Alkylation of papaverine carboanion with various alkyl halides is described.Intramolecular ring formation is observed with 1-iodo-3-chloropropane as electrophile. 1--6,7-dimethoxyisoquinoline is studied.

Method of forming a solution of papavrine carbanion

This invention relates to the new papaverine carbanion of the formula: STR1 and to a preparation process of the same comprising reacting on papaverine, in a solvent, a slight excess of a highly basic agent.