78095-21-3

Upstream product

• 1835-02-5 2-Bromo-1-(3,4-dimethoxyphenyl)ethanone 
• 14321-27-8 N-ethylbenzylamine 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 

Downstream Products

• 78095-24-6 N-ethyl-N-benzyl-2-(3,4-dimethoxyphenyl)-2-hydroxyethylamine 
• 345292-33-3 2-ethyl-4-(3',4'-dimethoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 
• 78095-29-1 2-ethyl-4-(3',4'-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline hydrobromide 

Relevant academic research and scientific papers

Dopamine Agonist Properties of N-Alkyl-4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines

A series of homologous N-alkyl-4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines was synthesized and examined for a dopamine-like ability to dilate the renal artery.The N-methyl derivative was equipotent to the 3',4'-dihydroxy derivative of the antidepressant agent nomifensine, indicating that the 8-amino group of the latter is not essential for dopamine-like activity.The N-ethyl homologue was reduced in potency when compared to the N-methyl, and the N-n-propyl, surprisingly, was essentially devoid of activity.This was unexpected in view of the fact that in all series of dopamine-like agents reported to date, N-alkylation, when one of the alkyls was an n-propyl group, either allowed retention or enhancement of potency.