78108-44-8

Upstream product

• 39959-51-8 2-iodobenzylamine 
• 407-25-0 trifluoroacetic anhydride 
• 7387-69-1 N-benzyl-2,2,2-trifluoroacetamide 

Downstream Products

• 160422-50-4 2,2,2-trifluoro-N-(2-iodobenzyl)-N-<4-(trimethylsilyl)but-2-ynyl>acetamide 
• 1374393-14-2 N-allyl-2,2,2-trifluoro-N-(2-iodobenzyl)acetamide 
• 1374393-17-5 2,2,2-trifluoro-1-[4-methylene-3,4-dihydroisoquinolin-2(1H)-yl]-ethanone 
• 78089-63-1 (α-Amino-2-tolyl)methylphosphinic Acid 
• 78108-45-9 (α-Amino-2-tolyl)methylphosphonic Acid Hydrochloride 
• 78089-61-9 Ethyl <α-(Trifluoroacetamido)-2-tolyl>methylphosphinate 

Relevant academic research and scientific papers

Direct ortho iodination of β- and γ-aryl alkylamine derivatives

Two in one! A trifluoroacetamide protecting group not only masks an amine functionality, but also mimics peptidyl directing effects as a controlling unit in an efficient ortho iodination of a variety of biologically relevant small molecules (see example). (Chemical Equation Presented).

Stereoselective Synthesis of Exocyclic Allylsilanes by Intramolecular Reductive Heck Cyclisation of Propargylsilanes

The stereoselective palladium-catalysed synthesis of the heterocycles 13-15 with a (Z)-exocyclic allylsilane moiety is described.Alkylation of the secondary amides 5a, 5b, 9a, and 9b and the phenol 11 containing an iodoaryl moiety with the propargyl iodid

Synthesis of Novel Phosphorus Heterocycles: 2-Aryl-1-methyl-2,3-dihydro-1H-2,1-benzazaphosphole 1-Oxides

A class of novel phosphorus heterocycles, 2-aryl-1-methyl-2,3-dihydro-1H-2,1-benzazaphosphole 1-oxides (1), has been prepared, beginning with the nickel-catalyzed Arbuzov reaction of diethyl methylphosphonite and o-iodotoluene and ending with an intramole