78128-76-4Relevant academic research and scientific papers
Structure-activity relationship for (+)-taxifolin isolated from silymarin as an inhibitor of amyloid β aggregation
Sato, Mizuho,Murakami, Kazuma,Uno, Mayumi,Ikubo, Haruko,Nakagawa, Yu,Katayama, Sumie,Akagi, Ken-Ichi,Irie, Kazuhiro
, p. 1100 - 1103 (2013)
Silymarin, the seed extract of Silybium marianum, has preventive effects against Alzheimer's disease-like pathogenesis in vivo. We isolated (+)-taxifolin (4) from silymarin as an inhibitor of aggregation of the 42- residue amyloid -protein. Structure-activity relationship studies revealed the 30,40-dihydroxyl groups to be critical to the anti-aggregative ability, whereas the 7-hydroxyl group and the stereochemistry at positions 2 and 3 were not important.
