78132-61-3Relevant academic research and scientific papers
TRANSMISSION D'UN EFFET STERIQUE PERI A TRAVERS UN NOYAU HETEROAROMATIQUE-I SYNTHESE ET PROPRIETES SPECTRALES DE DIALKYLIMIDAZO a>PYRIDINES PERI DISUBSTITUEES
Maury, G.,Pigiere, C.
, p. 83 - 90 (1981)
The regiospecificity of the condensation of 2-amino-pyridines and α-halo carbonyl compounds has been established and exists even in the occurrence of steric effects.Using this regiospecificity peri disubstituted imidazoa>pyridines have been prepared. (13)C and P NMR studies show profound differences between the spectra of peri disubstituted compounds and other disubstituted imidazoa>pyridines.These differences have been interpreted in terms of peri steric effects; preferential conformations of the peri alkyl substituents are postulated.
