78133-16-1Relevant academic research and scientific papers
Cp2TiCl2-CATALYZED GRIGNARD EXCHANGE REACTIONS WITH ACETYLENES. A CONVENIENT METHOD FOR PREPARATION OF E-ALKENYL GRIGNARD REAGENTS
Sato, Fumie,Ishikawa, Hiroaki,Sato, Masao
, p. 85 - 88 (2007/10/02)
Disubstituted acetylenes react with isobutylmagnesium halide in the presence of a catalytic amount of Cp2TiCl2 in ether to afford E-alkenyl Grignard reagents selectively and in almost quantitative yields.The regiochemistry of this hydromagnesation reaction is high for alkylarylacetylenes and silylacetylenes giving E-ArC(MgBr)=CHR from alkylarylacetylenes, E-ArC(MgBr)=CH(SiMe3) from arylsilylacetylenes, and E-CHR=C(MgBr)(SiMe3) from alkylsilylacetylenes, respectively.Thanks to the high reactivity of the Grignard reagent, the present reaction offers a novel, selective and operationally simple route for preparation of trisubstituted olefins.
