78156-47-5Relevant academic research and scientific papers
VARIATION OF SKELETONS OF ANTITUMOR ANTIBIOTICS I. SIMPLE SYNTHESIS OF NAPHTHOQUINOLINES AND A NAPHTHOQUINOXALINE
Oda, Noriichi,Kobayashi, Kazuhiro,Ueda, Taisei,Ito, Isoo
, p. 857 - 859 (2007/10/02)
Simple synthesis of naphthoquinolines (III,VI,IX) and a naphthoquinoxaline (XII), which are a novel heterocyclic ring system, was carried out by the Diels-Alder reaction of 1,2-dimethylenecyclohexane (I) with quinoline-5,8-quinone(II,V,VIII) or quinoxaline-5,8-quinone (XI). Air oxidation of these adducts (III,VI,IX) in alcoholic alkaline solution gave tetrahydronaphthoquinolines(IV,VII,X).
