78157-26-3

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
6-(4-pyridinyl)-3(2H)-pyridazinone (SALTDATA: FREE) is employed as a key compound in pharmaceutical research and drug development due to its promising biological properties. Its potential applications include the development of new drugs targeting various diseases and conditions.
Used in Antibacterial Applications:
In the field of antibacterial applications, 6-(4-pyridinyl)-3(2H)-pyridazinone (SALTDATA: FREE) is used as an active ingredient to combat bacterial infections. Its antibacterial properties make it a valuable asset in the development of new antibiotics to address the growing issue of antibiotic resistance.
Used in Antifungal Applications:
6-(4-pyridinyl)-3(2H)-pyridazinone (SALTDATA: FREE) is also utilized in antifungal applications, serving as a component in the development of antifungal medications. Its antifungal properties contribute to the creation of treatments for various fungal infections.
Used in Antitumor Applications:
In the realm of antitumor applications, 6-(4-pyridinyl)-3(2H)-pyridazinone (SALTDATA: FREE) is used as a potential anticancer agent. Its antitumor properties are being studied for the development of new cancer therapies, offering hope for improved treatment options in the future.
Used as a Central Nervous System Depressant:
6-(4-pyridinyl)-3(2H)-pyridazinone (SALTDATA: FREE) has been investigated for its potential as a central nervous system depressant. This application could lead to the development of medications for the treatment of anxiety, insomnia, and other conditions related to the central nervous system.
Used as an Anti-inflammatory Agent:
Lastly, 6-(4-pyridinyl)-3(2H)-pyridazinone (SALTDATA: FREE) shows promise as an anti-inflammatory agent. Its potential in this area could result in the creation of new treatments for inflammatory diseases, such as arthritis and other chronic inflammatory conditions.

Upstream product

• 696-54-8 pyridine-4-aldoxime 
• 1122-54-9 methyl (4-pyridyl) ketone 
• 79472-17-6 3-chloro-6-(pyridin-4-yl)pyridazine 
• 1692-15-5 4-pyridylboronic acid 
• 1338225-40-3 C₉H₉NO₄ 
• 158840-84-7 ethyl 3-(4-pyridyl)-4,5-dihydroisoxazole-5-carboxylate 
• 160427-18-9 2-Hydroxy-4-oxo-4-pyridin-4-yl-butyric acid ethyl ester 
• 80843-48-7 2,3-dihydro-3-oxo-6-(4-pyridinyl)-4-pyridazinecarboxylic acid 
• 147849-83-0 4,5-Dihydro-4-hydroxy-6-(4-pyridyl)-3(2H)-pyridazinone 
• 298-12-4 Glyoxilic acid 

Downstream Products

• 79472-17-6 3-chloro-6-(pyridin-4-yl)pyridazine 
• 923061-48-7 C₁₆H₁₂ClN₃S 

Relevant academic research and scientific papers

Towards dual inhibitors of the MET kinase and WNT signaling pathway; Design, synthesis and biological evaluation

Both the kinase MET and the WNT signaling pathway are attractive targets in cancer therapy, and synergistic effects have previously been observed in animal models upon simultaneous inhibition. A strategy towards a designed multiple ligand of MET and WNT signaling is pursued based on the two hetero biaryl systems present in both the MET inhibitor tepotinib and WNT signaling inhibitor TC-E 5001. Initial screening was conducted to find the most suitable ring systems for further optimization, whereas a second screen explored modifications towards pyridazinones and triazolo pyridazines. Up to 54% reduction of WNT signaling activity at 10 μM concentration was achieved, however, only low affinities towards MET were observed. Overall, the thiophene substituted pyridazinone 40 was the best dual MET and WNT signaling inhibitor, with a 17% and 19% reduction of activity, respectively. Although further optimizations are needed to achieve more potent dual inhibitors, the strategy presented herein can be valuable towards the development of a dual inhibitor of MET and WNT signaling.

Discovery of substituted pyrazol-4-yl pyridazinone derivatives as novel c-Met kinase inhibitors

A series of pyridazin-3-one substituted with morpholino-pyrimidine derivatives was synthesized and evaluated as tyrosine kinase inhibitors against c-Met enzyme, and anti-proliferative activities of Hs746T human gastric cancer cell line. Most of compounds exhibited good biological activity, while compound 10, 12a, 14a displayed excellent c-Met enzyme inhibitory activities and Hs746T cell-based activities.

Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators

Excitatory amino acid transporter 2 (EAAT2) is the major glutamate transporter and functions to remove glutamate from synapses. A thiopyridazine derivative has been found to increase EAAT2 protein levels in astrocytes. A structure-activity relationship study revealed that several components of the molecule were required for activity, such as the thioether and pyridazine. Modification of the benzylthioether resulted in several derivatives (7-13, 7-15 and 7-17) that enhanced EAAT2 levels by >6-fold at concentrations 50 of 0.5 μM.

Novel pyridazinone derivatives as inhibitors of CDK2

The present invention relates to compounds according to the general formula (I), with the definitions of the substituents X, R1 and R2 given below in the text, as well as their physiologically acceptable salts, methods for producing these compounds and their use as pharmaceuticals. These compounds are kinase inhibitors, in particular inhibitors of the kinase CDK2 (cyclin-dependent kinase 2)

PYRIDAZINONE DERIVATIVES, METHODS FOR PRODUCING THEM AND THEIR USE AS PHARMACEUTICALS

The present invention relates to compounds according to the general formula (I), with the definitions of the substituents X, R1 and R2 given below in the text, as well as their physiologically acceptable salts, methods for producing these compounds and their use as pharmaceuticals. Formula (I) These compounds are kinase inhibitors, in particular inhibitors of the kinase GSK-15 30 (glycogen synthase kinase-3?).

Nitrile oxide [3+2] cycloaddition: Application to the synthesis of 6-substituted 3(2H)-pyridazinones and 6-substituted 4,5-dihydro-4-hydroxy-3(2H)-pyridazinones

An efficient method for the preparation of 6-substituted 3(2H)-pyridazinones and 6-substituted 4,5-dihydro-4-hydroxy-3(2H)-pyridazinones starting from 3,5-disubstituted 4,5-dihydroisoxazoles is described. N-O bond cleavage of the isoxazoline ring promoted

One-pot preparation of 6-substituted 3(2H)-pyridazinones from ketones

A one-pot process for the preparation of 6-phenyl-3(2H)-pyridazinone from acetophenone and glyoxylic acid has been investigated and shown to have wide utility in the preparation of 6- and 5,6-substituted 3(2H)-pyridazinones. Limitations to the process encountered with 2'-hydroxyacetophenone and with basic hetero-aromatic ketones have been overcome, and the processes described offer the rapid and efficient synthesis of many 6-substituted pyridazinones from readily available ketones.

NOVEL AMINATION OF 6-ARYL-3(2H)-PYRIDAZINONES WITH HYDRAZINE

Treatment of 6-aryl-3(2H)-pyridazinones with hydrazine hydrate gave 4-amino-6-aryl-3(2H)-pyridazinones