78159-19-0Relevant academic research and scientific papers
A general and practical Ni-catalyzed C-H perfluoroalkylation of (hetero)arenes
Zhang, Shaoke,Rotta-Loria, Nicolas,Weniger, Florian,Rabeah, Jabor,Neumann, Helfried,Taeschler, Christoph,Beller, Matthias
supporting information, p. 6723 - 6726 (2019/06/17)
A direct perfluoroalkylation of (hetero)arenes using the air- and moisture-stable complex (dppf)Ni(o-tol)Cl was developed (23 examples). The novel procedure allows for the synthesis of various fluorinated products and tolerates sensitive functional groups including aldehydes, free amino groups and several heterocycles.
Heterogeneous platinum-catalyzed C-H perfluoroalkylation of arenes and heteroarenes
He, Lin,Natte, Kishore,Rabeah, Jabor,Taeschler, Christoph,Neumann, Helfried,Brückner, Angelika,Beller, Matthias
supporting information, p. 4320 - 4324 (2015/04/14)
Fluorinated organic compounds are gaining increasing interest for life science applications. The replacement of hydrogen in arenes or heteroarenes by a perfluoroalkyl group has a profound influence on the physical and biological properties of such building blocks. Here, an operationally simple protocol for the direct C-H perfluoroalkylation of (hetero)arenes with RfI or RfBr has been developed, using a robust supported platinum catalyst. The ready availability of the starting materials, the excellent substrate tolerance, and the reusability of the catalyst make this method attractive for the synthesis of a variety of perfluoroalkyl-substituted aromatic compounds. Preliminary mechanistic studies revealed the formation of radicals to be crucial in the reaction system.
METHOD FOR PREPARATION OF ALKYLATED OR FLUORO, CHLORO AND FLUOROCHLORO ALKYLATED COMPOUNDS BY HETEROGENEOUS CATALYSIS
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Page/Page column 16-17, (2015/12/24)
The invention discloses a method for preparation of alkylated or fluoro, chloro and fluorochloro alkylated compounds by a heterogeneous Pt/C-catalyzed alkylation or fluoro, chloro and fluorochloro alkylation with alkyl halides or with fluoro, chloro and fluorochloro alkyl halides in the presence of Cs2C03 or CsHC03.
Palladium-catalyzed C-H perfluoroalkylation of arenes
Loy, Rebecca N.,Sanford, Melanie S.
supporting information; experimental part, p. 2548 - 2551 (2011/06/22)
A new Pd-catalyzed reaction for the coupling between perfluoroalkyl iodides (RFI) and simple aromatic substrates is described. The perfluoroalkylated arene products are obtained in good to excellent yields in the presence of a phosphine-ligated Pd catalyst and Cs2CO3 as a base. The development, optimization, scope, and preliminary mechanistic studies of these transformations are reported.
FLUOROALKYLATION OF AROMATIC COMPOUNDS
Cowell, Allan B.,Tamborski, Christ
, p. 345 - 356 (2007/10/02)
Perfluoroalkylation of benzene, halobenzenes, pyridine, furan and thiophene has been accomplished through thermolysis of perfluoroalkyl iodides (CF3I, n-C10F21I and RfORfI) in the presence of the appropriate aromatic compound.Yields of alkylated products vary depending on temperature, presence of an HI acceptor and reactants ratio.Isomeric mixtures are obtained with halobenzenes, pyridine and thiophene.Furan however yields only the alpha substituted product.
