781675-88-5Relevant academic research and scientific papers
Synthetic studies on mitotic kinesin Eg5 inhibitors: Synthesis and structure-activity relationships of novel 2,4,5-substituted-1,3,4-thiadiazoline derivatives
Yamamoto, Junichiro,Amishiro, Nobuyoshi,Kato, Kazuhiko,Ohta, Yoshihisa,Ino, Yoji,Araki, Mitsuharu,Tsujita, Tetsuya,Okamoto, Seiho,Takahashi, Takeshi,Kusaka, Hideaki,Akinaga, Shiro,Yamashita, Yoshinori,Nakai, Ryuichiro,Murakata, Chikara
, p. 3961 - 3963 (2014/09/17)
The 2,4,5-substituted-1,3,4-thiadiazoline derivative 1a has been identified as a new class of mitotic kinesin Eg5 inhibitor. With the aim of enhancement of the mitotic phase accumulation activity, structure optimization of side chains at the 2-, 4-, and 5
M-STAGE KINESIN INHIBITOR
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Page/Page column 81, (2010/11/08)
A mitotic kinesin Eg5 inhibitor which comprises a thiadiazoline derivative represented by the general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient: [wherein R1 represents a hydrogen atom and the like, R2 represents a hydrogen atom, -C(=W)R6 (wherein W represents an oxygen atom or a sulfur atom, and R6 represents substituted or unsubstituted lower alkyl and the like) and the like, R3 represents -C(=Z)R19 (wherein Z represents an oxygen atom or a sulfur atom, and R19 represents substituted or unsubstituted lower alkyl and the like) and the like, R4 represents substituted or unsubstituted lower alkyl and the like, and R5 represents substituted or unsubstituted aryl and the like] and the like are provided.
