78173-85-0

Upstream product

• 5780-07-4 3-methoxy-4,5-methylenedioxybenzaldehyde 
• 78173-83-8 (E)-3-methoxycarbonyl-4-<5-methoxy-3,4-(methylenedioxy)phenyl>but-3-enoic acid 
• 78173-84-9 3-methoxycarbonyl-4-(3-methoxy-4,5-methylenedioxyphenyl)butanoic acid 
• 78173-82-7 3-(3-methoxy-4,5-methylenedioxybenzyl)butyrolactone 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Downstream Products

• 50656-78-5 (+/-)-nirtetralin 
• 82423-77-6 r-1-(3,4-dimethoxyphenyl)-t-2,c-3-bishydroxymethyl-8-methoxy-6,7-methylenedioxy-1,2,3,4-tetrahydronaphthalene 
• 78173-80-5 (6aR,9aR,10S)-10-(3,4-Dimethoxy-phenyl)-4-methoxy-6a,7,9a,10-tetrahydro-6H-furo[3',4':6,7]naphtho[1,2-d][1,3]dioxol-9-one 
• 82423-76-5 r-1-(3,4-dimethoxyphenyl)-c-3-hydroxymethyl-8-methoxy-6,7-methylenedioxy-1,2,3,4-tetrahydronaphthalene-t-2-carboxylic acid lactone 

Relevant academic research and scientific papers

Structure and Synthesis of the Aryltetralin Lignans Hypophyllanthin and Nirtetralin

Structures previously suggested for hypophyllanthin, the major aryltetralin lignan constituent of Phyllanthus niruri are shown to be incorrect.The structure r-1-(3,4-dimethoxyphenyl)-6-methoxy-t-2,c-3-bismethoxymethyl-7,8-methylenedioxy-1,2,3,4-tetrahydronaphthalene (5) now proposed is confirmed by an unambiguous synthesis.Synthesis of the congener, nirtetralin, is also described.

STRUCTURE AND SYNTHESYS OF HYPOPHYLLANTHIN, NIRTETRALIN, PHYLTETRALIN AND LINTETRALIN

Structures propounded for the four aryltetralin lignan constituents isolated from Phyllanthus niruri Linn. are confirmed by syntheses of their (+/-)-forms.