78178-60-6

Upstream product

• 78178-59-3 ethyl-α-hydroxymethylene-4-benzyloxy-3-methoxyphenylacetate 
• 29973-91-9 4-benzyloxy-3-methoxyphenylacetic acid 
• 50463-56-4 4-benzyloxy-3-methoxyphenylacetic acid ethyl ester 

Downstream Products

• 200214-59-1 2-(4-Benzyloxy-3-methoxyphenyl)-3-hydroxy-propionic Acid 
• 78178-75-3 ethyl 1-<2-carbethoxy-2-(4'-benzyloxy-3'-methoxyphenyl)ethyl>pyrrolidinyl-2-acetate 

Relevant academic research and scientific papers

AMINO ACID DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS

There is provided compounds of formula I, wherein R 1, R 2, R 3, R x, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required as in thrombosis or as anticoagulants.

Synthesis of Substituted 6,7-Diphenyl-1,2,3,5,8,8a-hexahydroindolizines

Substituted 6,7-diphenyl-1,2,3,5,8,8a-hexahydroindolizines (28a to 28e) have been synthesized by two methods.In first method, condensation of substituted 2-phenacylpyrrolidines (24b to 24d) with substituted phenylacetylchlorides (2) affords substituted 2-