782-13-8

Upstream product

• 106731-03-7 1-chloro-2-(2-methylbenzyl)benzene 
• 623-26-7 terephthalonitrile 
• 16419-60-6 2-Methylphenylboronic acid 
• 22115-41-9 2-(bromomethyl)benzonitrile 

Downstream Products

• 31603-74-4 2-(2'-Methylbenzyl)-benzaldazin 
• 1276042-08-0 (2-(2-methylbenzoyl)phenyl)(p-tolyl)methanone 
• 500311-03-5 2-(2-methyl-benzyl)-benzophenone 

Relevant academic research and scientific papers

Visible-Light-Mediated Aromatic Substitution Reactions of Cyanoarenes with 4-Alkyl-1,4-dihydropyridines through Double Carbon-Carbon Bond Cleavage

Novel aromatic substitution reactions of cyanoarenes with 4-alkyl-1,4-dihydropyridines as alkylating reagents in the presence of a catalytic amount of a photoredox catalyst proceed smoothly to give the corresponding alkyl-substituted arenes in good to high yields. The present reaction system realizes a novel C-C bond-forming reaction between two fragments generated from the C-C bond-cleavage reactions of two independent substrates.

Copper-catalyzed benzylic C-H oxygenation under an oxygen atmosphere via N-H imines as an intramolecular directing group

Copper-catalyzed benzylic C-H oxygenation under an oxygen atmosphere was developed starting from carbonitriles and Grignard reagents via N-H imine intermediates. The present process is characterized by the following two-step sequence in a one-pot manner: (1) addition of Grignard reagents to carbonitriles to form N-H imines and (2) benzylic C-H oxygenation (C=O bond formation) triggered by 1,5-hydrogen atom transfer with transient iminyl copper species.