78205-50-2Relevant academic research and scientific papers
Studies on Anticancer Agents: Synthesis of Some Anthramycin Analogs and Actinocinyl Diamides
Singh, Rajeshwar,Jain, Padam C.,Anand, Nitya
, p. 129 - 131 (2007/10/02)
9,11-Dihydroxy-8-methyl-2,3,5,10,11,11a-hexahydro-1H-pyrrolobenzodiazepine (11) and actinocinyldipyrrolidines (4 and 5) have been synthesized starting from 3-benzyloxy-4-methyl-2-nitrobenzamides (2 and 3).Catalytic hydrogenation of 2 and 3 followed by oxidative dimerisation affords actinocinyldipyrrolidines ( 4 and 5).Ethyl 1-(3-benzyloxy-4-methyl-2-nitrobenzoyl)-L-prolinate (2) on reduction, followed by acid-catalysed cyclisation, hydrogenolysis, protection of the o-aminophenol functionality by preparing benzylidien derivative, NaBH4 reduction and deblocking gives required pyrrolobenzodiazepine (11).
