78216-79-2

Upstream product

• 1203458-24-5 (1R,2R,3R)-9-[2,3-dihydroxy-4-hydroxymethyl-4-cyclopenten-1-yl]-6-chloropurine 
• 78193-59-6 2'-O-triflyl-3',6'-O-(tetraisopropyldisiloxane-1,3-diyl)neplanocin A 
• 78193-60-9 Acetic acid (2R,3R,3aR)-2-(6-amino-purin-9-yl)-5,5,7,7-tetraisopropyl-2,3,3a,9-tetrahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-3-yl ester 
• 78193-58-5 3',6'-O-(tetraisopropyldisiloxane-1,3-diyl)neplanocin A 
• 72877-50-0 neplanocin A 
• 78193-65-4 Acetic acid (1R,2R,5R)-5-(6-amino-purin-9-yl)-2-hydroxy-3-hydroxymethyl-cyclopent-3-enyl ester 

Relevant academic research and scientific papers

A convergent approach for the synthesis of ara-neplanocin a analogues under subzero microwave assisted conditions

A convergent strategy for the synthesis of ara-neplanocin A analogues has been developed. Microwave assisted Mitsunobu reaction proved to be an essential tool both for the 2' - hydroxy inversion and for the coupling reaction with the heterocyclic bases. The exploitation of the present approach allowed generating a family of ara-neplanocins which biological potential is still unexplored.