78217-68-2

Upstream product

• 100-46-9 benzylamine 
• 107886-41-9 N,N-bis(4-phthalimidobutyl)benzylamine 
• 78217-67-1 N,N-Bis(3-cyanopropyl)-benzylamine 

Downstream Products

• 4427-76-3 sym-homospermidine 
• 622839-31-0 N-trityl-N'-[4-(trityl-amino)-butyl]-butane-1,4-diamine 
• 107886-67-9 N⁴,N⁹,N¹⁴-tribenzyl-N¹,N¹⁸-bis(phthaloyl)-4,9,14-triazaoctadecane 
• 107886-43-1 C₅₁H₅₇N₅O₄ 
• 107886-66-8 1-amino-N¹,N⁵,N⁹-tribenzyl-N⁹-(4-phthalimidobutyl)-5-azanonane 
• 107886-42-0 N,N'-Dibenzyl-N-(4-benzylamino-butyl)-butane-1,4-diamine 
• 78217-80-8 N⁵--N¹,N⁹-bis(2,3-dimethoxybenzoyl)bis(4-aminobutyl)amine 
• 78217-94-4 N¹,N⁹-bis(2,3-dihydroxybenzoyl)bis(4-aminobutyl)amine hydrobromide 
• 78217-82-0 N⁵--N¹,N⁹-bis(2,3-dihydroxybenzoyl)bis(4-aminobutyl)amine 
• 78217-77-3 N¹,N⁹-bis(2,3-dimethoxybenzoyl)bis(4-aminobutyl)amine 
• 78217-73-9 N⁵-benzyl-N¹,N⁹-bis(2,3-dimethoxybenzoyl)bis(4-aminobutyl)amine hydrochloride 

Relevant academic research and scientific papers

Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota

The availability of fully sequenced bacterial genomes has revealed that many species known to synthesize the polyamine spermidine lack the spermidine biosynthetic enzymes S-adenosylmethionine decarboxylase and spermidine synthase. We found that such speci

Xylylated dimers of putrescine and polyamines: Influence of the polyamine backbone on spermidine transport inhibition

Dimeric norspermidine and spermidine derivatives are strong competitive inhibitors of polyamine transport. A xylyl tether was used for the dimerization of various triamines and spermine via a secondary amino group, and of putrescine via an ether or an amino group. Dimerization of putrescine moieties potentiates their ability to compete against spermidine transport to a much greater extent than for triamine dimers.

Syntheses of a Series of Linear Pentaamines with Three and Four Methylene Chain Intervals

Ten kinds of linear pentaamines with various combinations of 3 or 4 methylene chain intervals were synthesized.The methods were tentatively classified into two, leading to symmetrical and unsymmetrical pentaamines, all of which were prepared by succesive alkylation of secondary amino derivatives of benzylamine with N-(3-bromopropyl or 4-bromobutyl)phthalimide in the presence of KF-Celite, coupled with the purification of the phthaloyl compounds by silica gel column chromatography.Protecting benzyl and phthaloyl groups were removed by usual methods.The carbon-13 nuclear magnetic resonance (13C-NMR) spectra ot the ten pentaamines were recorded in D2O as fully protonated forms, and a comparative analysis of their spectra allowed the complete assignment of all 13C chemical shifts.Keywords-polyamine; pentaamine; benzylamine; N-(3-bromopropyl)phthalimide; N-(4-bromobutyl)phthalimide; alkylation; potassium fluoride-Celite; 13C-NMR spectrum