78217-75-1

Upstream product

• 1521-38-6 2,3-dimethoxybenzoic acid 
• 78217-69-3 N⁴-benzyl-N¹,N⁸-bis(2,3-dimethoxybenzoyl)spermidine hydrochloride 
• 124-20-9 N-(3-aminopropyl)-1,4-diaminobutane 
• 73038-05-8 N-(3-aminobutyl)-N-(3-aminopropyl)(phenylmethyl)amine 
• 1216-04-2 N-(2-Cyanoethyl)-N-(3-cyanopropyl)-benzylamine 

Downstream Products

• 82247-45-8 N⁴-(N-carbobenzoxy-L-threonyl)-N¹,N⁸-bis(2,3-dimethoxybenzoyl)spermidine 
• 244761-46-4 N5,N5-thiodipropanoyl-bis 
• 74149-70-5 parabactin 
• 89675-85-4 N⁴-L-threonyl-N¹,N⁸-bis(2,3-dimethoxybenzoyl)spermidine 
• 82247-46-9 N¹,N⁸-bis(2,3-dihydroxybenzoyl)-M⁴-(L-threonyl)spermidine hydrobromide 
• 78217-90-0 N⁴--N¹,N⁸-bis(2,3-dihydroxybenzoyl)spermidine 
• 78217-91-1 N⁴-<4-<(2,3-dihydroxybenzoyl)amino>butyryl>-N¹,N⁸-bis(2,3-dihydroxybenzoyl)spermidine 
• 78217-89-7 N⁴--N¹,N⁸-bis(2,3-dihydroxybenzoyl)spermidine 
• 76927-62-3 3-<(2,3-dihydroxybenzoylamino)propyl>-N-<4-(2,3-dihydroxy-benzoylamino)butyl>-2-hydroxybenzoyl-glycylamide 
• 117680-12-3 N⁴-(N-Methyl-N-(benzyloxy)succinamoyl)-N¹,N⁸-bis(2,3-bis(methyloxy)benzoyl)spermidine 
• 117680-10-1 N⁴-Succinoyl-N¹,N⁸-bis(2,3-bis(methyloxy)benzoyl)spermidine 
• 78217-93-3 N¹,N⁸-bis(2,3-dihydroxybenzoyl)spermidine hydrobromide 
• 117680-07-6 N⁴-((p-Nitrobenzyl)succinoyl)-N¹,N⁸-bis(2,3-bis(dimethyloxy)benzoyl)spermidine 
• 78217-78-4 N⁴--N¹,N⁸-bis(2,3-dimethoxybenzoyl)spermidine 

Relevant academic research and scientific papers

Synthesis and electrochemical studies of a new iron tetra-catecholamide complex

A new tetra-catecholamide compound N5,N6-thiodipropanoyl-bis[N1,N10- bis(2,3-dihydroxybenzoyl-spermidine)] (H8L) has been synthesised as an iron chelator of Fe (III). Cyclic voltammogram of the iron complex H2LFe run under an argon atmosphere shows a quasi-reversible redox process with E0 = - 430 mV vs. SCE in CH3OH/H2O (60/40). This value approaches the range of biological reductants and consequently the complex may mimic the release of iron from enterobactin to the agents which are directly involved in cell metabolism.

Spermexatin and Spermexatol: New Synthetic Spermidine-Based Siderophore Analogues

Syntheses of hexanediamine-based dihydroxamate (Hexamate), spermidine-based trihydroxamate (Spermexatins), and spermidine-based mixed siderophore analogues (Spermexatols) are described.Key intermediates include the N-hydroxysuccinimide esters of various hydroxamic acids, e.g., malonohydroxamate, succinohydroxamate, and glutarohydroxamate.These intermediates were synthesized, characterized, and incorporated as the ligating chains on spermidine.Also, mixed iron chelating compounds (Spermexatols) with both catechol and hydroxamic acid side chains were synthesized.Thereagent carbobenzoxyimidazole was employed to distinguish between the primary and secondary amino groups of spermidine.The ability of these iron chelators to stimulate microbial growth is also described.