78224-47-2

Usage

Uses

Used in Pharmaceutical Research:
Methyl 8-Methoxyquinoline-2-carboxylate is used as a key intermediate in the synthesis of pharmaceuticals for its potential biological activities, including antimicrobial, antitumor, and antiviral properties. Its unique structure allows it to be a promising candidate in the development of new drugs.
Used in Organic Synthesis:
In the field of organic synthesis, Methyl 8-Methoxyquinoline-2-carboxylate is used as a building block for the synthesis of various heterocyclic compounds. Its versatile chemical properties make it a valuable component in creating complex organic molecules.
Used in Antimicrobial Applications:
Methyl 8-Methoxyquinoline-2-carboxylate is used as an antimicrobial agent, leveraging its potential biological activities to combat various microorganisms, making it a useful compound in the development of antimicrobial drugs and treatments.
Used in Antitumor Applications:
In the realm of antitumor research, Methyl 8-Methoxyquinoline-2-carboxylate is used for its potential to inhibit tumor growth, making it a candidate for the development of cancer treatments and therapies.
Used in Antiviral Applications:
Methyl 8-Methoxyquinoline-2-carboxylate is also used in antiviral applications, where its biological activities can be harnessed to inhibit viral replication and spread, contributing to the development of antiviral medications.

Upstream product

• 1571-30-8 8-hydroxy-quinoline-2-carboxylic acid 
• 74-88-4 methyl iodide 
• 90-04-0 2-methoxy-phenylamine 

Relevant academic research and scientific papers

Development of Potent Inhibitors of the Mycobacterium tuberculosis Virulence Factor Zmp1 and Evaluation of Their Effect on Mycobacterial Survival inside Macrophages

The enzyme Zmp1 is a zinc-containing peptidase that plays a critical role in the pathogenicity of Mycobacterium tuberculosis. Herein we describe the identification of a small set of Zmp1 inhibitors based on a novel 8-hydroxyquinoline-2-hydroxamate scaffold. Among the synthesized compounds, N-(benzyloxy)-8-hydroxyquinoline-2-carboxamide (1 c) was found to be the most potent Zmp1 inhibitor known to date, and its binding mode was analyzed both by kinetics studies and molecular modeling, identifying critical interactions of 1 c with the zinc ion and residues in the active site. The effect of 1 c on intracellular Mycobacterium survival was assayed in J774 murine macrophages infected with M. tuberculosis H37Rv or M. bovis BCG and human monocyte-derived macrophages infected with M. tuberculosis H37Rv. Cytotoxicity and genotoxicity were also assessed. Overall, inhibitor 1 c displays interesting in vitro antitubercular properties worthy of further investigation.

Facile Construction of Quinoline-2-carboxylate Esters through Aerobic Oxidation of Alkyl 4-Anilinocrotonates Induced by a Radical Cation Salt

A facile construction of quinoline-2-carboxylate esters through an aerobic oxidation of alkyl 4-anilinocrotonates is described. In the presence of dioxygen, sp3 C?H bonds in 4-anilinocrotonates can easily be oxidized by using a catalytic amount of a radical cation salt, providing a radical intermediate. After further oxidation and domino cyclization, the desired quinoline derivatives were afforded in high yields. This reaction provides a new way to construct the pharmaceutically relevant quinoline skeleton, avoiding harsh reaction conditions and tedious starting material synthesis.