Bromo-PEG3-Acid is a PEG (polyethylene glycol) linker that features a bromide group on one end and a terminal carboxylic acid on the other end. This molecule is designed to enhance solubility in aqueous media due to the hydrophilic nature of the PEG spacer, which consists of three PEG units. The bromide serves as an excellent leaving group for nucleophilic substitution reactions, while the terminal carboxylic acid can form stable amide bonds with primary amine groups in the presence of appropriate activators, such as EDC or HATU.
782475-35-8
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Basic information
- Product Name: Bromo-PEG3-Acid
- Synonyms: Br-PEG3-acid;Bromo-PEG3-propionic acid
- CAS NO:782475-35-8
- Molecular Formula: C9H17BrO5
- Molecular Weight: 285.13228
- EINECS: N/A
- Product Categories: N/A
- Mol File: 782475-35-8.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: -20°C
- Solubility: Soluble in Water, DMSO, DMF, DCM
- CAS DataBase Reference: Bromo-PEG3-Acid(CAS DataBase Reference)
- NIST Chemistry Reference: Bromo-PEG3-Acid(782475-35-8)
- EPA Substance Registry System: Bromo-PEG3-Acid(782475-35-8)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 782475-35-8(Hazardous Substances Data)
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782475-35-8 Usage
Uses
Used in Bioconjugation:Bromo-PEG3-Acid is used as a crosslinker for bioconjugation applications, allowing the stable attachment of molecules, such as proteins or other biomolecules, through the formation of amide bonds with their primary amine groups.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Bromo-PEG3-Acid is used as a component in drug delivery systems, where its solubility-enhancing properties and ability to form stable bonds can improve the delivery, bioavailability, and therapeutic outcomes of various drugs.
Used in Material Science:
In material science, Bromo-PEG3-Acid can be utilized as a building block for the development of novel materials with specific properties, such as hydrogels or other PEG-based materials, by taking advantage of its solubility and reactivity.
Used in Chemical Synthesis:
Bromo-PEG3-Acid serves as a versatile intermediate in chemical synthesis, particularly in the creation of PEGylated compounds, which can have enhanced solubility and stability compared to their non-PEGylated counterparts.
Check Digit Verification of cas no
The CAS Registry Mumber 782475-35-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,8,2,4,7 and 5 respectively; the second part has 2 digits, 3 and 5 respectively.Calculate Digit Verification of CAS Registry Number 782475-35:
(8*7)+(7*8)+(6*2)+(5*4)+(4*7)+(3*5)+(2*3)+(1*5)=198
198 % 10 = 8
So 782475-35-8 is a valid CAS Registry Number.
782475-35-8Upstream product
782475-35-8Downstream Products
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Bromo-PEG3-Acid
