782479-05-4Relevant academic research and scientific papers
New air-stable ruthenium olefin metathesis precatalysts derived from bisphenol S
Bieniek, Micha?,Bujok, Robert,Stepowska, Halszka,Jacobi, Albrecht,Hagenk?tter, Robert,Arlt, Dieter,Jarzembska, Katarzyna,Makal, Anna,Wo?niak, Krzysztof,Grela, Karol
, p. 5289 - 5297 (2006)
Synthesis and screening of catalytic activity of novel mono- and diruthenium carbene complexes 7a and 7b prepared from inexpensive Bisphenol S via Claisen rearrangement-isomerisation route is described. These catalysts constitute an excellent tool for rin
Efficient large-scale synthesis of BILN 2061, a potent HCV protease inhibitor, by a convergent approach based on ring-closing metathesis
Yee, Nathan K.,Farina, Vittorio,Houpis, Ioannis N.,Haddad, Nizar,Frutos, Rogelio P.,Gallou, Fabrice,Wang, Xiao-Jun,Wei, Xudong,Simpson, Robert D.,Feng, Xuwu,Fuchs, Victor,Xu, Yibo,Tan, Jonathan,Zhang, Li,Xu, Jinghua,Smith-Keenan, Lana L.,Vitous, Jana,Ridges, Michael D.,Spinelli, Earl M.,Johnson, Michael,Donsbach, Kai,Nicola, Thomas,Brenner, Michael,Winter, Eric,Kreye, Paul,Samstag, Wendelin
, p. 7133 - 7145 (2007/10/03)
A multistep scalable synthesis of the clinically important hepatitis C virus (HCV) protease inhibitor BILN 2061 (1) is described. The synthesis is highly convergent and consists of two amide bond formations, one etherification, and one ring-closing metath
Olefin ring-closing metathesis as a powerful tool in drug discovery and development - potent macrocyclic inhibitors of the hepatitis C virus NS3 protease
Tsantrizos, Youla S.,Ferland, Jean-Marie,McClory, Andrew,Poirier, Martin,Farina, Vittorio,Yee, Nathan K.,Wang, Xiao-jun,Haddad, Nizar,Wei, Xudong,Xu, Jinghua,Zhang, Li
, p. 5163 - 5171 (2007/10/03)
Peptidomimetic inhibitors of the hepatitis C NS3 protease often exhibit poor biopharmaceutical properties. Structure modification of a substrate-based tripeptide into a β-strand 15-membered ring scaffold provided a new class of peptidomimetics that are si
NOVEL METATHESIS CATALYSTS
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Page/Page column 12-13, (2008/06/13)
The invention relates to novel compounds of formula (1), the preparation thereof, intermediate products for the preparation thereof, and the use of the compounds of formula (1) as catalysts in different metathesis reactions. Said novel metathesis catalyst
