782480-41-5

Upstream product

• 6165-68-0 thiophene boronic acid 
• 782480-54-0 (3-S)-4-iodo-N-(1-benzyl-3-pyrrolidinyl)benzamide 
• 871233-08-8 (S)-3-(4-Thiophen-2-yl-benzoylamino)-pyrrolidine-1-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 1711-02-0 4-iodobenzoic acid chloride 
• 114715-38-7 (3S)-1-benzyl-3-pyrrolidinamine 
• 871233-12-4 N-pyrrolidin-3-yl-4-thiophen-2-yl-benzamide 
• 100-44-7 benzyl chloride 

Downstream Products

• 871233-08-8 (S)-3-(4-Thiophen-2-yl-benzoylamino)-pyrrolidine-1-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 871233-12-4 N-pyrrolidin-3-yl-4-thiophen-2-yl-benzamide 

Relevant academic research and scientific papers

N-[(3S)-1-Benzylpyrrolidin-3-yl]-(2-thienyl)benzamides: Human dopamine D4 ligands with high affinity for the 5-HT2A receptor

A series of N-[(3S)-1-benzylpyrrolidin-3-yl]-(2-thienyl)benzamides 8 has been prepared and found to bind with high affinity to the human D4 (hD4) and 5-HT2A receptors. Several compounds displayed selectivity for these rece

N-(1-Benzylpyrrolidin-3-yl)arylbenzamides as potent and selective human dopamine D4 antagonists

A series of N-(1-benzylpyrrolidin-3-yl)arylbenzamides 8 has been prepared, and their structure-activity relationships studied. Potent ligands selective for human D4 (hD4) over hD2 and α1 have been identified. One example was determined to be an antagonist in a cAMP assay, with an IC50 of 1500 nM. A series of N-(1-benzylpyrrolidin-3-yl)arylbenzamides 8 has been prepared, and their structure-activity relationships studied. Potent ligands selective for human D4 (hD4) over hD2 and α1 have been identified. One example was determined to be an antagonist in a cAMP assay, with an IC50 of 1500 nM.