782492-17-5Relevant articles and documents
Discovery of a potent and orally bioavailable CCR2 and CCR5 dual antagonist
Pasternak, Alexander,Goble, Stephen D.,Struthers, Mary,Vicario, Pasquale P.,Ayala, Julia M.,Di Salvo, Jerry,Kilburn, Ruth,Wisniewski, Thomas,Demartino, Julie A.,Mills, Sander G.,Yang, Lihu
scheme or table, p. 14 - 18 (2010/11/04)
This report describes the discovery of a potent, orally bioavailable CC chemokine receptor 2 (CCR2) antagonist which, while optimized for CCR2 potency, also had potent CC chemokine receptor 5 (CCR5) activity.
BENZOXAZINYL-AMIDOCYCLOPENTYL-HETEROCYCLIC MODULATORS OF CHEMOKINE RECEPTORS
-
Page 64, (2010/02/09)
Cyclopentyl compounds linked to a benzoxazinyl group through an amido moiety utilizing the ring nitrogen of the benzoxazine, and further substituted with a heterocyclic moiety, such compounds represented by formula (I): which are used to modulate the CCR-