782493-13-4

Basic information

• Product Name: Cyclopentanecarboxylic acid, 1-(1-methylethyl)-3-oxo-, (1S)- (9CI)
• Synonyms: Cyclopentanecarboxylic acid, 1-(1-methylethyl)-3-oxo-, (1S)- (9CI)
• CAS NO: 782493-13-4
• Molecular Formula: C₉H₁₄O₃
• Molecular Weight: 170.20566
• Product Categories: ISOPROPYL
• Mol File: 782493-13-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Cyclopentanecarboxylic acid, 1-(1-methylethyl)-3-oxo-, (1S)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopentanecarboxylic acid, 1-(1-methylethyl)-3-oxo-, (1S)- (9CI)(782493-13-4)
• EPA Substance Registry System: Cyclopentanecarboxylic acid, 1-(1-methylethyl)-3-oxo-, (1S)- (9CI)(782493-13-4)

Safety Data

• Hazardous Substances Data: 782493-13-4(Hazardous Substances Data)

Upstream product

• 782493-16-7 benzyl (1S)-1-isopropyl-3-oxocyclopentanecarboxylic acid 
• 1016979-15-9 aminoacid salt 
• 400770-74-3 1-isopropyl-3,3-dimethoxyyclopentanecarboxylate 
• 400770-75-4 1-isopropyl-3-oxocyclopentanoyl chloride 
• 400771-20-2 tert-butyl 3,3-dimethoxycyclopentanecarboxylate 
• 782493-15-6 tert-butyl 1-isopropyl-3,3-dimethoxycyclopentanecarboxylate 
• 693246-00-3 benzyl 1-isopropyl-3-oxocyclopentanecarboxylic acid 
• 624734-32-3 (1S,4S)-4-[(tert-butoxycarbonyl)amino]-1-isopropylcyclopent-2-ene-1-carboxylic acid 
• 624734-29-8 (1S,3R)-methyl-3-[(tert-butoxycarbonyl)amino]-1-isopropylcyclopentanecarboxylate 
• 624734-30-1 (1S,3R)-3-((tert-butoxycarbonyl)amino)-1-isopropylcyclopentane-1-carboxylic acid 
• 624734-28-7 C₂₀H₂₁NO₂ 
• 693245-59-9 C₂₃H₂₇NO₂ 
• 765298-45-1 C₁₀H₁₉NO₂*ClH 
• 98-78-2 3-Oxo-cyclopentanecarboxylic acid 

Downstream Products

• 782493-18-9 (1S)-N-[2-tert-butoxy-5-(trifluoromethyl)benzyl]-1-isopropyl-3-oxocyclopentanecarboxamide 

Relevant articles and documents

Discovery of a potent and orally bioavailable CCR2 and CCR5 dual antagonist

This report describes the discovery of a potent, orally bioavailable CC chemokine receptor 2 (CCR2) antagonist which, while optimized for CCR2 potency, also had potent CC chemokine receptor 5 (CCR5) activity.

BENZOXAZINYL-AMIDOCYCLOPENTYL-HETEROCYCLIC MODULATORS OF CHEMOKINE RECEPTORS

Cyclopentyl compounds linked to a benzoxazinyl group through an amido moiety utilizing the ring nitrogen of the benzoxazine, and further substituted with a heterocyclic moiety, such compounds represented by formula I: which are used to modulate the CCR-2 chemokine receptor to prevent or treat inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis; and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions.

HETEROCYCLIC CYCLOPENTYL TETRAHYDROISOQUINOLINE AND TETRAHYDROPYRIDOPYRIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

The present invention is directed to compounds of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X, n and the broken lines are as defined herein which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.