782496-81-5Relevant articles and documents
Design, synthesis, and biological evaluation of cyclic and acyclic nitrobenzylphosphoramide mustards for E. coli nitroreductase activation
Jiang, Yongying,Han, Jiye,Yu, Chengzhi,Vass, Simon O.,Searle, Peter F.,Browne, Patrick,Knox, Richard J.,Hu, Longqin
, p. 4333 - 4343 (2007/10/03)
In efforts to obtain anticancer prodrugs for antibody-directed or gene-directed enzyme prodrug therapy using E. coli nitroreductase, a series of nitrobenzylphosphoramide mustards were designed and synthesized incorporating a strategically placed nitro gro