78254-55-4Relevant academic research and scientific papers
One-pot system for reduction of epoxides using NaBH4, PdCl 2 catalyst, and moist alumina
Yakabe, Shigetaka
, p. 1339 - 1344 (2010)
Reduction of epoxides with sodium borohydride, a catalytic amount of palladium(II) chloride, and chromatographic neutral alumina preloaded with a small amount of water (moist alumina) in hexane gave alcohols in good to excellent yields and good selectivity of the desired products under mild conditions. The reaction system was operationally simple and environmentally friendly. The alumina can be recovered simply and reused a number of times without any treatment and with good activity.
DEUTERATED COMPOUNDS AS ROCK INHIBITORS
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Paragraph 105; 113; 142; 143, (2019/10/15)
Provided are compounds of Formular (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising these compounds thereof, and use of these compounds in preparing drugs for inhibiting ROCK.
Selective A2A receptor antagonist
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, (2018/12/14)
The invention provides a selective A2A receptor antagonist. In specific, the invention provides the selective A2A receptor antagonist shown in the formula (I), a drug composition containing the same and the pharmacy application and treatment application t
5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THE SAME, MEDICINAL USE THEREOF AND INTERMEDIATES IN THE PRODUCTION THEREOF
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Page 19, (2010/02/07)
The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is an optionally substituted lower alkyl group, an optionally substituted lower alkoxy group, an optionally substituted lower alkenyl group, a cycloalkyl group or a lower acyl group etc.; Q is a hydrogen atom or an optionally substituted lower alkyl group; and Z is a hydrogen atom or a hydroxy group etc., or a pharmaceutically acceptable salt thereof, which exert a potent and selective activated blood coagulation factor X inhibitory activity and is useful as an agent for the prevention or treatment of a disease occurred associating an activated blood coagulation factor X, a pharmaceutical composition comprising the same and an intermediate thereof. These compounds are useful as preventives or remedies for various diseases such as brain infarction, cerebral thrombosis, cerebral embolism, TIA, cerebral vascular jerk, Alzheimer's diseases, myocardial infarction, heart attack, heart failure, thrombosis, pulmonary infarction and pulmonary embolism.
