78262-57-4Relevant academic research and scientific papers
ANTIHISTAMINIC IMIDAZOLES
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, (2008/06/13)
The present invention provides compounds of the general formula (I) STR1 and physiologically acceptable salts and bioprecursors thereof in which STR2 represents either STR3 R 1 represents hydrogen, halogen, C 1-4 alkoxy, hydroxy, alkyl, R 4 CH(OH)--, cyano or R. sup.5 CONH--, R 2 and R 3, which may be the same or different, each represents a straight or branched chain alkyl group or alkenyl group or R 2 and R. sup.3 may, together with the nitrogen atom to which they are attached, form a saturated heterocyclic ring containing from 5 to 7 members which may optionally contain an oxygen atom; R 4 represents hydrogen or alkyl; and R 5 represents hydrogen, alkyl or C 1-4 alkoxy. The compounds have been shown to exhibit H 1-antagonist activity in standard pharmacological tests.
