78307-61-6

Upstream product

• 40400-13-3 2-Iodobenzyl bromide 
• 96541-52-5 2-(4-methylanilino)-2-(4-chlorophenyl)acetonitrile 
• 78307-53-6 (3S,3aR)-3-(4-Chloro-phenyl)-1-p-tolyl-3,3a-dihydro-1H-cyclohepta[c]isothiazole 2,2-dioxide 

Relevant academic research and scientific papers

Synthesis of 1,2-Disubstituted Indoles from α-Aminonitriles and 2-Halobenzyl Halides

The α-alkylation of deprotonated Strecker products derived from primary amines and aromatic aldehydes with 2-halobenzyl halides furnishes intermediates that can be cyclized to 1,2-disubstituted indoles in moderate to high yields (up to 94% over two steps) by microwave-assisted copper- or palladium-catalyzed intramolecular cross-coupling.

Oxidative Conversions of Sulfene Cycloadducts from Azaheptafulvenes and from Tropone to 1,2-Disubstituted Indoles and 2-Arylbenzofurans, Respectively

The cycloadducts from azaheptafulvenes and sulfenes as well as from tropone and arylsulfenes rearrange upon oxidation of their corresponding α-sulfonyl anions to give 1,2-disubstituted indoles and 2-arylbenzofurans.