78312-54-6

Basic information

• Product Name: 4-(2-Oxo-5-thioxo-1-piperidinyl)-2-triphenylphosphorandiylbuttersaeure-ethylester
• CAS NO: 78312-54-6
• Molecular Weight: 503.602
• Mol File: 78312-54-6.mol

Chemical Properties

• CAS DataBase Reference: 4-(2-Oxo-5-thioxo-1-piperidinyl)-2-triphenylphosphorandiylbuttersaeure-ethylester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-Oxo-5-thioxo-1-piperidinyl)-2-triphenylphosphorandiylbuttersaeure-ethylester(78312-54-6)
• EPA Substance Registry System: 4-(2-Oxo-5-thioxo-1-piperidinyl)-2-triphenylphosphorandiylbuttersaeure-ethylester(78312-54-6)

Safety Data

• Hazardous Substances Data: 78312-54-6(Hazardous Substances Data)

Upstream product

• 5693-95-8 6-thioxo-2-piperidinone 

Relevant articles and documents

A DIASTEREOSELECTIVE ROUTE TO (+/-)-ISORETRONECANOL

N-Unsubstituted imides react with 1-carboethoxycyclopropyltriphenylphosphonium tetrafluoroborate to yield N-acyl-Δ2-pyrroline, pyrrolizidine, and indolizidine derivatives. -

Reaction of Cyclic Imides with 1-Ethoxycarbonylcyclopropyltriphenylphosphonium Tetrafluoroborate: A Simple Diastereoselective Route to (+/-)-Isoretronecanol

Bicyclic N-bridgehead lactams 2 and 3 are obtained by reacting the anions of succinimide and glutarimide with the cyclopropylphosphonium salt 1.Starting from 2 a diastereoselective synthesis of (+/-)-isoretronecanol (7) is achieved.The adducts 10, which are obtained from monothioimide anions and 1, do not cyclize regioselectively.Dehydrogenation of 2 using N-bromosuccinimide yields the 5,6-dihydropyrrolizine 11; however, reaction with lead tetraacetate gives the isomer 12.Succinimide reacts with the cyclopropylphosphonium salt 13 to give the pyrrolizidine 14.