78324-75-1

Usage

Uses

Used in Pharmaceutical Industry:
3,4,5-Trifluorobenzamide is used as a key intermediate in the synthesis of N-(diphenylphosphoryl)benzamide derivatives, which are of significant interest in the pharmaceutical industry. These derivatives have potential applications as therapeutic agents, particularly in the development of new drugs targeting various diseases.
Used in Chemical Research:
3,4,5-Trifluorobenzamide is also used as a research compound in chemical laboratories. Its unique structure and reactivity make it a valuable tool for studying the effects of fluorination on the properties of organic molecules and for exploring new synthetic pathways and reactions.
Used in Material Science:
In the field of material science, 3,4,5-trifluorobenzamide can be utilized in the development of new materials with specific properties. Its fluorinated structure can contribute to the design of materials with enhanced stability, reactivity, or selectivity, which can be applied in various industrial processes or technologies.

InChI:InChI=1/C7H4F3NO/c8-4-1-3(7(11)12)2-5(9)6(4)10/h1-2H,(H2,11,12)

Upstream product

• 132123-54-7 3,4,5-trifluorobenzaldehyde 
• 121602-93-5 3,4,5-trifluorobenzoic acid 

Relevant academic research and scientific papers

Stable and reusable nanoscale Fe2O3-catalyzed aerobic oxidation process for the selective synthesis of nitriles and primary amides

The sustainable introduction of nitrogen moieties in the form of nitrile or amide groups in functionalized molecules is of fundamental interest because nitrogen-containing motifs are found in a large number of life science molecules, natural products and materials. Hence, the synthesis and functionalization of nitriles and amides from easily available starting materials using cost-effective catalysts and green reagents is highly desired. In this regard, herein we report the nanoscale iron oxide-catalyzed environmentally benign synthesis of nitriles and primary amides from aldehydes and aqueous ammonia in the presence of 1 bar O2 or air. Under mild reaction conditions, this iron-catalyzed aerobic oxidation process proceeds to synthesise functionalized and structurally diverse aromatic, aliphatic and heterocyclic nitriles. Additionally, applying this iron-based protocol, primary amides have also been prepared in a water medium.

CYCLIC AMINE COMPOUND

A compound represented by the formula (I) or a salt thereof: (I) wherein the ring A represents a 5- to 8-membered ring which may have additional substituent besides R6, R7 and R8; R1 represents an electron-attracting group; R2, R3, R4 and R5 independently represent a hydrogen atom, a halogen atom, a group attached through a carbon atom, a group attached through a nitrogen atom, a group attached through an oxygen group, or a group attached through a sulfur atom; R6 represents a halogen atom, a group attached through a carbon atom, a group attached through a nitrogen atom, a group attached through an oxygen group, or a group attached through a sulfur atom, and R7 represents a cyano group, a nitro group, an acyl group which may have a substituent, a carboxyl group which may be esterified or amidated, or a hydrocarbon group which may have a substituent, or R6 and R7 together with a carbon atom to which they are attached may form a ring which may have a substituent; and R8 represents a hydrogen atom, a halogen atom, a group attached through a carbon atom, a group attached through an oxygen atom, or a group attached through a sulfur atom. The compound or salt has an excellent androgen receptor modulating effect, and is useful for the prevention/treatment of hypogonadism, partial androgen deficiency in aging male, decline in physical strength, cachexia, osteoporosis and the like.