78331-30-3Relevant academic research and scientific papers
Degradation of azaglycinamido residues in model tripeptides derived from goserelin
Hoitink, Marnix A.,Beijnen, Jos H.,Bult, Auke,Damen, J. Mirjam A.,Van Der Houwen, Oeds A. G. J.,Kruijtzer, John A. W.,Tibben, Matthijs M.,Wiese, Gerard,Underberg, Willy J. M.
, p. 108 - 114 (2007/10/03)
Three model tripeptides, N-acetyl-Tyr-Pro-azaGly-NH2 (NYPaG), Tyr-Pro- azaGly-NH2 (YPaG), and Tyr-Pro-Gly-NH2(YPG), were subjected to a systematic degradation study to get information about the degradation of the azaglycinamido residue The degradation products were characterized with LC- MS. Main degradation products of NYPaG possess partially or totally eliminated azaglycinamido residues, while YPaG and YPG are exhibit cyclo(Tyr- Pro) formation, a diketopiperazine. The influence of the pH on the degradation rate constant k(obs) was investigated for NYPaG and YPaG in the pH range 0.4-11. An U-shaped profile with an inflexion around pH 9 was found for NYPaG while the degradation rate of YPaG was independent of the pH. NYPaG apparently was subject to proton-, solvent-, and hydroxyl-catalyzed degradation reactions whereas YPaG only underwent solvent-catalyzed reactions. Some influence of acetate and phosphate ions on k(obs) was found for YPaG. Arrhenius plots of NYPaG and YPaG were found to be linear. (C) 2000 Wiley-Liss, Inc.
SYNTHESIS OF HBsAG SEGMENTS IN SOLUTION
Schoen, I.,Szirtes, T.,Rill, A.
, p. 751 - 773 (2007/10/02)
Immunization with segments (117-137 and 121-137) of the surface antigen of hepatitis B virus (HBsAg) had been reported to protect against HB infection.Therefore in addition to these peptides, HBsAg(124-137) and the three C-terminally amidated derivatives
