78341-04-5

Upstream product

• 79228-18-5 (10R,11R,11aS,11bR)-11a-Ethyl-11-hydroxy-2,3,4,5,10,11,11a,11b-octahydro-1H-3a,9b-diaza-benzo[cd]fluoranthene-10-carboxylic acid methyl ester 
• 51049-28-6 14,15-dihydro-21-nor-1,14-secoeburnamenin-20-al 
• 96-34-4 methyl chloroacetate 
• 51152-47-7 (1R*,5S*,12bS*)-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizine-1-carbaldehyde 
• 74571-79-2 1-ethyl-2,3,4,6,7,12-hexahydroindolo<2,3-a>quinolizin-4-thione 
• 169530-52-3 (1R*,5R*,12bR*)-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizine-1-carbaldehyde 
• 25328-05-6 1α-ethyl-1-(2-hydroxy-2-methoxycarbonylethyl)-1,2,3,4,6,7,12,12bβ-octahydroindolo<2,3-a>quinolizine 
• 18374-19-1 (+/-)-3H-epivincamine 
• 51049-26-4 (1R,12bR)-1-Ethyl-1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizine-1-carbaldehyde 
• 64361-56-4 1α-ethyl-1β-(hydroxymethyl)-1,2,3,4,6,7,12,12bβ-octahydroindolo<2,3-a>quinolizine 
• 66685-08-3 1-ethyl-2,3,4,6,7,12-hexahydroindolo<2,3-a>quinolizin-4(1H)-one 
• 66685-13-0 4-(4,9-dihydro-3H-β-carbolin-1-yl)-hexanoic acid methyl ester 
• 55390-29-9 1-ethyl-2,3,4,6,7,12-hexahydro-indolo(2,3-a)quinolizinium perchlorate 
• 106498-98-0 (1R*,5R*,12bR*)-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizine-1-methanol 

Downstream Products

• 21019-23-8 deoxyvincamine 

Relevant academic research and scientific papers

A NEW APPROACH TO (+/-)-APOVINCAMINE

A new approach to (+/-)-apovincamine, 2, is reported which bypasses the formation of (+/-)-vincamine, 1, and includes the dehydration of the β-hydroxy ester 7, obtained by regio-controlled alkylation of the stereochemically suitable aldehyde 6 with methyl chloroacetate.Using ethyl chloroacetate, the clinically useful apovincamine analogue, (+/-)-Cavinton, 3, is obtained. (+/-)-Apovincamine is then converted to (+/-)-vincamine, 1, by base-catalyzed oxygenation of the mixture of (+/-)-dihydroapovincamines 8 and 9.