78344-67-9

Upstream product

• 1198212-37-1 ethyl 5-(4-chlorophenyl)-2-diazo-5-hydroxy-3-oxopentanoate 
• 58303-62-1 5-(4-chlorophenyl)-2,3-dihydrofuran-2,3-dione 
• 623-73-4 diazoacetic acid ethyl ester 
• 84905-28-2 3-(4-Chloro-phenyl)-propene-1,3-dione 

Downstream Products

• 1198212-38-2 ethyl 5-(4-chlorophenyl)-3-oxo-2,3-dihydrofuran-2-carboxylate 
• 78344-75-9 5-(4-Chloro-benzoyl)-4-oxo-4,5-dihydro-1H-pyrazole-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Construction of two vicinal quaternary carbons by asymmetric allylic alkylation: Total synthesis of hyperolactone C and (-)-biyouyanagin A

Call on triple A: Palladium-catalyzed asymmetric allylic alkylation (Pd-AAA; see scheme) has enabled a concise and efficient synthesis of hyperolacto ne C and (-)-biyouyanagin A in only six (20% Overall yield) and seven (8% overall yield) steps, respectively. The enantiomers of these natural products were also prepared by exploiting the same methodology.

Polarographic behavior of ethyl esters of substituted diazoacetic and diazopyruvic acids

Polarographic reduction of ethyl 5-aryl-2-diazo-3,5-dioxopentanoate and ethyl 6-aryl-3-diazo-2,4,6-trioxohexanoate in isopropanol-water solutions proceeds with three or four polarographic waves and yields, depending on the pH of the solution, pyridazine or pyrazolidine derivatives.

CHEMISTRY OF OXALYL DERIVATIVES OF METHYL KETONES. XXV. SYNTHESIS AND CYCLIZATION OF 2-DIAZO-1,5-DIARYL-1,3,5-PENTANETRIONES AND 2-DIAZO-5-ARYL-3,5-DIOXOPENTANOIC ESTERS

2-Diazo-1,5-diaryl-1,3,5-pentanetriones and ethyl 2-diazo-5-aryl-3,5-dioxopentanoates were obtained in the reaction of 5-aryl-2,3-dihydro-2,3-furandiones with aroyldiazomethanes and diazoacetic ester.In some cases the formation of diazopentanetriones is a