78347-95-2

Upstream product

• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 36155-85-8 2-chloro-4-thiophenecarboxaldehyde 
• 63909-55-7 diethyl 2-bromobenzylphosphonate 
• 78370-87-3 (E)-4-<2-(2'-bromophenyl)ethenyl>-2-chlorothiophene 

Downstream Products

• 74168-80-2 5-chloro-3-(2-phenylethyl)-2-thiophenecarboxylic acid 

Relevant academic research and scientific papers

LITHIATION OF SOME 3THIOPHENES AND INTRAMOLECULAR TRANSMETALATION

The reaction of some halo-1-(thienyl)-2-phenylethanes such as 3-(2-phenylethyl)thiophene (1), 3-thiophene (2), 4--2-methylthiophene (3) and 4--2-chlorothiophene (4) with butyllithium and lithium diisopropylamide (LDA) under various conditions has been investigated.Competition between halogen-metal exchange in the benzene ring and metalation of thiophene ring was observed and an intramolecular transmetalation reaction was found.